Vitas-M Laboratory Ltd and MolTech Ltd have joined their efforts to design next generation of focused libraries. We have called this project Lilac.

The process of targeted library design for particular protein target includes three stages:

-       Docking-based virtual screening of the entire screening library (stock) against therapeutic target using Lead Finder software with further ranking of all chemical compounds according to calculated Virtual Screening score (VS-score).

-       Tuning of Lead Finder scoring function/parameters by docking and calculating VS-score for a set of known active chemical substances extracted from the public scientific sources.

-       Repeat calculating of VS-score for the whole chemical library and re-ranking molecules according to target-optimal scoring function. Further selection of top-scored compounds to comprise the desired focused library.

The detailed description of selection route is available on the MolTech wb site.

Why it is worthwhile to buy Vitas-M Laboratory’s targeted libraries?

• We use unique software developed by our colleagues from MolTech.
• We use double refining process that ensures that only top scored compounds that passed through  VS-scoring twice are included into the list.
• You can get targeted library of the size you wish (from 100 items till whatever you need and want).

Right now request samples of Lilac databases and the full list of targets!